We situate the well-trodden debate about defining health and disease within the project of a metaphysics of science and its aim to work with and contribute to science. We make use of Guay and Pradeu’s ‘metaphysical box’ to reframe this debate, showing what is at stake in recent attempts to move beyond it, revealing unforeseen points of agreement and disagreement among new and old positions, and producing new questions that may lead to progress. We then discuss the implications of the (...) two-way benefits between medicine and philosophy when the latter is driven and constrained by medical science. (shrink)

This essay discusses four key criticisms recently leveled against the main attempts to use conceptual analysis to understand health and disease. First, it examines the weaknesses of these attempts and suggests a better way to proceed. Next, it briefly discusses another disease debate concerning pathological mechanisms and suggests that this approach could be more fruitful than that of conceptual analysis. The final section demonstrates how Georges Canguilhem's biological philosophy of disease avoids some of the problems associated with conceptual analysis, and (...) how he can contribute to both debates. Canguilhem's appeal to biological normativity is understood as contributing to a theoretical explanation, and a possible naturalization, of what is specific to healthy and pathological phenomena. (shrink)

This chapter elucidates one small sliver of the developments within the philosophy of mind. It has the dual aim of (a) clarifying Chaba's account of cognition and its objects and (b) examining some of the more profound philosophical consequences that flow from this Kadam Tibetan understanding of cognition. The first half of the chapter elucidates the Kadam understanding of the phenomenology of cognition. Here, the author argues that Chaba and his followers should be seen as endorsing a disjunctive theory of (...) perception. The second half takes up the issue of intentionality and how cognition engages objects that are not directly present to it. The author shows that Chaba's categorization of cognitive states forces him to adopt a strong form of cognitive externalism. (shrink)

The last two decades have witnessed a crescendo of allegations that clinical translation is rife with waste and inefficiency. Patient advocates argue that excessively demanding regulations delay access to life‐saving drugs, research funders claim that too much basic science languishes in academic laboratories, journal editors allege that biased reporting squanders public investment in biomedical research, and drug companies (and their critics) argue that far too much is expended in pharmaceutical development.But how should stakeholders evaluate the efficiency of translation and proposed (...) reforms to drug development? Effective reforms require an accurate model of the systems they aspire to improve—their components, their proper functions, and their pathologies. However, there is currently no explicit and well‐developed model of translation for evaluating such criticisms.In what follows, we offer an explicit model of clinical translation. Many discussions of clinical translation and its pathologies presume that its main output is tangible: new drugs, vaccines, devices, and diagnostics. We disagree. We argue that the principal output of clinical translation is information—in particular, information about the coordinated set of materials, practices, and constraints needed to safely unlock the therapeutic or preventive activities of drugs, biologics, and diagnostics. To develop this information calls for a process far different from a simple linear progression of clinical trials; it requires exploratory sampling of many different elements in this set. Our model points to some limitations and liabilities of influential proposals for reforming research. It also reveals some underrecognized opportunities for improving the efficiency of clinical translation. (shrink)

Metaphysical semantics is supposed to connect the nonfundamental to the fundamental in a distinctively “linguistic” way, explaining how nonfundamental truths can be grounded in fundamental facts , and so inducing a radically eliminative vision of the nonfundamental as mere talk. I wonder how the story goes when a single nonfundamental truth can be grounded in many different fundamental facts. For instance, the truth that Moore has hands can presumably be grounded in many different distributions of fields, arrangements of particles, vibrations (...) of strings, or whatnot. I am asking how metaphysical semantics can accommodate this sort of multiple realizability. (shrink)

Experimental manipulations are a key means to establish causal relationships in microbiology. However, challenges remain to establish the applicability of such experiments beyond the precise conditions in which they were conducted. Ecological information can help address these challenges by describing the extent to which an experimentally-determined mechanism can explain the natural phenomenon that it is purported to cause.

Probably the most successful scientific theory ever created, quantum theory has profoundly changed our view of the world and extended the limits of our knowledge, impacting both the theoretical interpretation of a tremendous range of phenomena and the practical development of a host of technological breakthroughs. Yet for all its success, quantum theory remains utterly baffling. Quantum Reality: Theory and Philosophy cuts through much of the confusion to provide readers with an exploration of quantum theory that is as authoritatively comprehensive (...) as it is intriguingly comprehensible. Requiring no more than school level physics and mathematics background, this volume requires only an interest in understanding how quantum theory came to be and the myriad ways it both explains how our universe functions and extends the reach of human knowledge. Written by well-known physics author and teacher Dr. Jonathan Allday, this highly engaging work: Presents a thorough grounding in the theoretical machinery of quantum physics Offers a whistle-stop tour through the early part of the 20th century when the founding fathers of quantum theory forever altered the frontiers of human thought Provides an example-filled interpretation of the theory, its applications, and its pinnacle in quantum field theory (QFT), so crucial in shaping ideas about the nature of reality Separates fact from speculation regarding quantum physics’ ability to provide a starting point for philosophical queries into ultimate understanding and the limits of science The world beneath the one that we experience with our senses is profoundly mysterious, and while we may never completely unravel that mystery, quantum theory allows us to come closer than ever to understanding where the science leaves off and the mystery begins. Quantum Reality: Theory and Philosophy makes that understanding accessible to anyone possessing a quest for knowledge and a sense of awe. (shrink)

A critique of conversational epistemic contextualism focusing initially on why pragmatic encroachment for knowledge is to be avoided. The data for pragmatic encroachment by way of greater costs of error and the complementary means to raise standards of introducing counter-possibilities are argued to be accountable for by prudence, fallibility and pragmatics. This theme is sharpened by a contrast in recommendations: holding a number of factors constant, when allegedly higher standards for knowing hold, invariantists still recommend assertion (action), while contextualists do (...) not. Given the knowledge norm of assertion, if one recommendation is preferable to the other, the result favors the preferred recommendation's account of knowledge. In the final section, I offer a unification of these criticisms centering on the contextualist use of 'epistemic position'. Their use imposes on threshold notions of justification, warrant, or knowledge tests that are suitable only to unlimited comparative or scalar notions like confidence or certainty and places them at one with an important strand of sceptical reasoning. (shrink)

The *Kāśyapaparivarta, an early Mahāyāna sūtra, has a complex history. Sanskrit and Tibetan versions, and some of its Chinese translations, have been available to scholars for almost a century, thanks to Staël-Holstein’s 1926 editio princeps. Yet no comprehensive survey of available sources, or critical appraisal of their antecedants, has been published, and most importantly, essential Chinese materials have long been overlooked. The present contribution focuses most centrally on the Chinese translations of the scripture. In addition, the relation of the sūtra (...) to the Mahāratnakūṭa collection of forty-nine texts and the possible Indic origins of the latter are explored. (shrink)

Focuses on techniques that help you successfully capture sports and live action photographs, such as freezing action or adding motion blur Covers getting the right gear, setting your camera for the shot, capturing the shot, editing the ...

Federal policies on human subjects research have performed a near‐about face. In the 1970s, policies were motivated chiefly by a belief that subjects needed protection from the harms and risks of research. Now the driving concern is that patients, and the populations they represent, need access to the benefits of research.

: Despite its mandate on minimizing harms in clinical trials, the Common Rule provides little guidance as to how IRBs should evaluate risk. The Common Rule and derivative commentaries tend to conceptualize risk review as an expert-based endeavor aimed at an objective and universal evaluation of possible harm; they also have tended to locate risk in the research activity itself rather than in the context of the research. These views of risk conflict with scholarship showing that risk evaluations are socially (...) determined even among experts, that the context of harms can influence how persons evaluate risks, and that forums that approach risk assessment as a technical endeavor bracket from discussion the numerous values that ground risk judgments. Possible reforms are proposed for clinical trial risk review that would render it more inclusive of the different types of risks encountered and more attuned to the priorities of trial subjects. (shrink)

Introduction : ethical economics? -- The sovereign consumer -- Two myths about economic growth -- The politics of pay -- Happiness -- Pricing life and nature -- New worlds of money : public services and beyond -- Conclusion.

Jonathan Dancy; I *—The Presidential Address: Why there is really No Such Thing as the Theory of Motivation, Proceedings of the Aristotelian Society, Volume 95.

This article makes four claims. First, that the analytic/Continental split in political theory stems from an unarticulated disagreement about human nature, with analytics believing we have an innate set of mostly compatible moral and political inclinations, and Continentals seeing such things as alterable products of historical contingency. Second, that we would do better to talk of Continental-political-theory versus Rawlsian-political-philosophy, given that the former avoids arguments over principles, whilst the latter leaves genuine analytic philosophy behind. Third, that Continentals suffer from a (...) lack of such arguments, even by their own lights, whilst Rawlsians suffer from inconsistencies within the thought-patterns on which their principles depend. Fourth, that there is an alternative method – ‘normative behaviourism’ – that at least tries to move beyond the problems of both approaches, whilst sharing an idea of ‘praxis’ with the first, and an idea of deriving-principles-from-existing-judgements with the second. (shrink)

Existence Value has become an increasingly important concept as the use of cost benefit analysis has spread from traditional applications to attempts to place monetary value on, for instance, a rare wetland habitat. Environmental economists have generally accepted the tensions arising in the existence value concept from the range of recent applications, but it is argued here that their various attempts to resolve the difficulties have largely failed. Critics from outside economics, on the other hand, typically claim that the very (...) notion of existence value as understood in economics is flawed, and urge its abandonment altogether. This paper suggests instead a fundamental redefinition of existence value, which, it is argued, (i) explains a number of diverse problems posed by the usual meaning of the term in economics; (ii) does not strain the intentions of respondents to ' willingness-to-pay' surveys; (iii) is consistent with a more realistic model of rational choice in environmental decision-making; and (iv) is sensitive to criticisms from environmental ethics.2. (shrink)

Written by leading theorists and empirical researchers, this book presents new ways of addressing the old question: Why did religion first emerge and then continue to evolve in all human societies? The authors of the book--each with a different background across the social sciences and humanities -- assimilate conceptual leads and empirical findings from anthropology, evolutionary biology, evolutionary sociology, neurology, primate behavioral studies, explanations of human interaction and group dynamics, and a wide range of religious scholarship to construct a deeper (...) and more powerful explanation of the origins and subsequent evolutionary development of religions than can be currently found in what is now vast literature. While explaining religion has been a central question in many disciplines for a long time, this book draws upon a much wider array of literatures to develop a robust and cross-disciplinary analysis of religion. The book remains true to its subtitle by emphasizing an array of both biological and sociocultural forms of selection dynamics that are fundamental to explaining religion as a universal institution in human societies. In addition to Darwinian selection, which can explain the biology and neurology of religion, the book outlines a set of four additional types of sociocultural natural selection that can explain fill out the explanation of why religion first emerged as an institutional system in human societies, and why it has continued to evolve over the last 200,000 years of societal evolution. These sociocultural forms of natural selection are labeled by the names of the early sociologists who first emphasized them; and these can be seen as a necessary supplement to the type of natural selection theorized by Charles Darwin. Explanations of religion that remain in the shadow cast by Darwin's great insights will, it is argued, remain narrow and incomplete when explaining a robust sociocultural phenomena like religion. (shrink)

Many commentators have expressed concern that large investments in biomedical research over the past two decades have not been translated effectively into clinical applications. In its Critical Path Report, the Food and Drug Administration characterized the problem as a “technological disconnect between discovery and the product development process,” and documented that the number of investigational new drugs submitted to the agency had declined “significantly” since 2000. Along a similar vein, another study found that only five of 101 basic science studies (...) showing significant therapeutic promise were successfully translated into clinical applications.This perceived translational lag is stimulating a shift toward human testing of study interventions earlier in the drug development process. One indication of this trend is a recent guidance encouraging sponsors to pursue human “exploratory” studies before embarking on phase I trials. (shrink)

Bioethics as a field has been fortunate that its values and concerns have mirrored the values and concerns of society. In light of the September 11th attacks, it is possible that we are witnessing the beginning of a transition in American culture, one fraught with implications for bioethics. The emphasis on autonomy and individual rights may come to be tempered by greater concern over the collective good. Increased emphasis on solidarity over autonomy could greatly alter public response to research abuses (...) aimed at defense from bioterrorism, to privacy of genetic information, and to control of private medical resources to protect the public health. (shrink)

The Food and Drug Administration and the European Agency for the Evaluation of Medicinal Products recently issued documents encouraging sponsors to consider microdose testing before launching Phase I trials, and many commentators predict that such methodologies will be applied more routinely in drug development. However, exploratory testing has provoked several ethical criticisms. Skeptics question the value and validity of microdose trials, and whether they present a reasonable balance of risks and benefits for subjects. Another major criticism is that such studies (...) serve mainly commercial ends. The present article explores these and other ethical concerns for studies conducted in the oncology setting. It concludes that microdosing is not inconsistent with prevailing practices in Phase I research, and that in principle, such studies could strengthen the ethical basis for Phase I trials by providing them better evidentiary justification. (shrink)

The United Kingdom has many bodies that play their part in carrying out the work of national ethics committees, but its nearest equivalent of a U.S. presidential bioethics commission is the Nuffield Council on Bioethics, established in 1991. The Council is charged with examining ethical questions raised by developments in biological and medical research, publishing reports, and making representations to appropriate bodies in order to respond to or anticipate public concern. It is a nongovernment organization with no defined or guaranteed (...) channels of influence. It has no authority merely by virtue of the position it holds. Rather, it has established relational authority based on its reputation. Unlike the U.S. bioethics commission, it is not part of executive government, nor is it constituted to contribute to the legislative branch, as does the French Comité Consultatif National d'Ethique. Its nongovernmental status notwithstanding, the Nuffield Council's work affects the U.K. government and the British public, and the Council has achieved international recognition for its reports. I was the chairperson from 2012 to 2017 and draw on my experience in this piece to consider three key audiences: governments, publics, and the international community. (shrink)

Michael WiIliams maintains that skepticism about the extemal worId is vitiated by a commitment to foundationalism and epistemological realism. (The latter is, approximately, the view that there is such a thing as knowledge of the extemal world in general, which the skeptic can take as a target). I argue that skepticism is not encumbered in the ways Williams supposes. What matters, first of all, is that we can’t perceive the difference between being in an ordinary environment and being in the (...) sort of situation the skeptic describes (e.g. having one’s brain manipulated by deceitful experimenters). This point can be upheld without embracing any substantial foundationalist tenet, such as the existence of basic beliefs, the availabiIity of something “given,” or the epistemic priority of experience. As to “epistemological realism,” I find that Williams has offered no principled way to distinguish between ordinary chaIIenges to knowledge and skeptical challenges which, supposedly, have no cIaim on our concem. (shrink)

Griffiths and Machery contend that the concept of innateness should be dispensed with in the sciences. We contend that, once that concept is properly understood as what we have called 'closed process invariance', it is still of significant use in the sciences, especially cognitive science.

This chapter contains sections titled: Epistemological Background Educational Applications On Not Addressing Epistemological Controversies.

The concept of justice, a cornerstone in Aristotle's political philosophy, holds intrinsic significance in both historical and contemporary contexts. This article embarks on an intricate exploration of the primacy of global justice within Aristotle's philosophical framework and its far-reaching implications in addressing contemporary challenges. Drawing from Aristotle's perspective on justice within the polis, the article navigates the terrain of his ideas, extending them beyond conventional boundaries and examining their pertinence in the global arena. Aristotle's nuanced definitions of justice lay the (...) foundation for dissecting its role within the community. The dichotomy of distributive and corrective justice adds depth to the discussion, setting the stage for the exploration of justice on a global scale. Indications within Aristotle's writings hint at a broader consideration of justice, encompassing global concerns that transcend political boundaries. The resonance between Aristotle's principles and contemporary global issues, including poverty, environmental degradation, and human rights violations, is brought to light through the Sustainable Development Goals (SDGs). This alignment underscores the enduring relevance of Aristotle's philosophy and its potential to inform contemporary ethical paradigms. Furthermore, the article contemplates the influence of Aristotle's justice-centred ideas on international relations, envisioning its impact on diplomacy, cooperation, and conflict resolution. Acknowledging critiques and counterarguments that question the adaptability of Aristotle's theories to modern complexities, the article upholds the enduring applicability of his principles. Aristotle's emphasis on equilibrium and rectification offers a portal for addressing multifaceted global injustices, even in the intricate web of contemporary interdependence. The article culminates in the assertion that the primacy of global justice within Aristotle's political philosophy reverberates profoundly in the present day. The convergence of his principles with contemporary ethical frameworks, the potential implications on international diplomacy, and the adaptability to intricate global challenges substantiate the perpetual wisdom encapsulated in Aristotle's ideas. Embracing the essence of his philosophy, humanity is poised to forge a path toward a more just, harmonious, and equitable world. (shrink)